Searchable abstracts of presentations at key conferences in endocrinology

ea0016p626 | Reproduction | ECE2008

Influence of the 5 α-reductase inhibitor type 2 on circulating neuroactive steroids

Duskova Michaela , Hill Martin , Hanus Miroslav , Matouskova Michaela , Starka Luboslav

The 5α-reductase is one of the enzyme of steroid synthesis and founded in two isoformes. Two distinct 5α-reductase isoenzymes, type I and type II, are found across mammalian species. Each of these isoenzymes is differentially expressed in tissues and during distinct developmental stages and also in different species. The 5α-reductase is enzyme responsible for the reduction of testosterone to dihydrostestosterone, progesterone to dihydroprogesterone and deoxycort...